Association between mitochondrial DNA haplogroup and myelodysplastic syndromes
نویسندگان
چکیده
منابع مشابه
A link between mitochondrial DNA haplogroup and ischemia.
diseases collectively known as mitochondrial disease and including multisystem disorders. Mitochondrial DNA (mtDNA) mutations also manifest in disturbing the reactive oxygen species balance in the cell, leading to diverse pathological conditions. The maternally inherited mtDNA does not undergo biparental recombination but accumulating polymorphisms have been forming branches of the phylogenetic...
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Etiology of myelodysplastic syndromes The models for the development of sporadic MDS suggest the role of cumulative environmental exposures in genetically predisposed individuals. There is increasing evidence for a complex genetic predisposition to MDS involving naturally occurring DNA polymorphisms in genes that mediate DNA repair and metabolize environmental carcinogens.3 Large epidemiologic ...
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Mitochondrial DNA (mtDNA) variation has recently been suggested to have an association with various cancers, including prostate cancer risk, in human populations. Since mtDNA is haploid and lacks recombination, specific mutations in the mtDNA genome associated with human diseases arise and remain in particular genetic backgrounds referred to as haplogroups. To assess the possible contribution o...
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PURPOSE Mitochondrial DNA (mtDNA) haplogroups affect the clinical expression of Leber hereditary optic neuropathy, age-related macular degeneration, and other diseases. The objective of this study is to investigate whether an mtDNA background is associated with myopia. METHODS Blood DNA was obtained from 192 college students, including 96 individuals with moderate-to-high myopia and 96 contro...
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ژورنال
عنوان ژورنال: Genes, Chromosomes and Cancer
سال: 2016
ISSN: 1045-2257
DOI: 10.1002/gcc.22370